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Hernando De Soto's expedition undoubtedly passed (1540-42) through the region, then inhabited by the Choctaw, Chickasaw, and Natchez, but the first permanent European settlement was not made until 1699, when Pierre le Moyne, sieur d'Iberville, established a French colony on Biloxi Bay. Settlement accelerated in 1718, when the colony came under the French Mississippi Company, headed by the speculator John Law.
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